omega-necro-bump! this was my issue too! modlist was long and worked except for as described. I'd get a flicker and then many script-based keystrokes would cease to be registered with their scripts. e.g.
Immersive Minimap II which uses AB Script hook
SSM (simple slow motion) which uses ScriptHookRDR@DotNet-V2
turns out I was using ThirteenAG's Ultimate-ASI-Loader which I found in pinned comment on kepmehz's nexus here
This caused me a PILE of needless binary search removals in a row until I was close to down to just these problem mods.
All other script-based keystrokes also stopped working probably, just these were the ones I instantly noticed. now it works, oh happy day. modding is great when it's great and just as bad when it's bad.
Asi's
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AmbientRandomEvents.asi
Banking.asi
Boats.asi
Bountydialogues.asi
BucketWash.asi
CampAnywhere.asi
CampfireWeaponLocker.asi
CollectablesInRange.asi
Companion.asi
Contracts.asi
CutVoicelineRestoration.asi
DisableCameraShake.asi
DisableHorseHolstering.asi
DogComapnion.asi
DragPeds_Natural.asi
DumpThatCargo1.1.asi
EarlyFishing1.0.asi
EquineDucking.asi
Fisherman.asi
FishingRodGripToggle.asi
GatlingWagons.asi
Graves.asi
GunTricks.asi
HatBlip2.0.asi
horseLantern.asi
HorseLoadout.asi
Houses.asi
HuntingCamp.asi
InteractionTargetMarker.asi
LOS Enemy Blips.asi
Minimap.asi
MoreZoomWhileAiming.asi
NativeTrainer.asi
NoBulletTrail.asi
NoDeadEyeEffects.asi
NoHitmarker.asi
NoHonorLossForLawAnimals.asi
NoInvisibleSnipers.asi
NoReticleSpread.asi
NoWeaponDegradation.asi
Pay.asi
PedDamageOverhaul.asi
PredatorsRework.asi
QuickDraw.asi
RDR2.asi
RemoveSpeedLimits.asi
RestoredCutContent-Quiver1.6.6.asi
SafeShopping.asi
ScriptHookRDRDotNet.asi
ShoveInsteadTackle.asi
StashThatLantern2.8.asi
TieYourLasso.asi
vfs.asi
WalkingControlComplete.asi
LML
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25% Faster Holstering Unholstering
4.75 (RDR2 scale 5.1)
7.5 (RDR2 scale 7.85)
Actually Long Long Barrels
Ambient Gang - RDR1 Gang
ambient gangs + realistic loadouts patch
animations
Best_TAA_and_Visual_Effects
beta douglas fir
Better Camera
better-pumps
bountyhunterDEI
ChapterVideos
CleanHorse
Coat Physics Fixes
CompsonsPistol
Corpse Spawn Distance
cowhandFix
Cut Content Dogs Unlocked for SP
Deputy's Badge - Merge
Detach
Disabled all map culling
DWW Soundtrack v1.1
easier_gold
EquineDucking
EXTRA_LITE_Multiplayer Asset Enabler
FastMapZoom
FirstPersonFOVMod
Floating Horseshoe Fix + Placeholder Posters Fix
Gameplay
Graphical issue fixes
Herbalist
HideOnlineButton
Higher Res Ui
Higher Resolution Vegetation
Horse Animation Fix
Horse Eye Draw Distance Fix
Horse Overhaul Mod 1.03.23532
Horse Overhaul Mod Compendium and Challenge Fix
HORSE_LITE_Multiplayer_Asset_Enabler
Hovering gun fix
ImprovementsInBlood
JailBreak Fix
Javier Poster Fix
JM R&E
JustFuckingBleed
JustUseTheCrossAlready
Legendary Channel Catfish Restored
lodscale 1.75-2.0
Longer Girthier Springfield
M91 Carcano
Model Fixes
mods.xml
movies_0
No More Medals in Notifications (Black)
No Police Whistle Sound
No_More_Grindy_Challenges
Online Bears Unlocked for SP
Patch (ambientpedmodelsets.meta)
Patch (goals_sp.meta)
Patch (metapeds.ymt)
Patch (systemsettings.ymt)
Patch (timecycle_mods_1-2.xml)
Patch (visualsettings.dat)
patterns.dat
PDO v2.0 Extended Features
Ped Accuracy Fix
Period Accurate Currency
PhysicalWorldMaps
QoL - Artie and Johnny
R.W.A.O
Real Catalog Rework
RealisticStDenisSchedule
Realistic_Loadouts v2.4 for Ambient Gang
Refitted Bandoliers - Shirts and Vests
replace
Sheriff Dialogue Restored
shutupalready
SkyVideos
Smaller DBS
Snappy.UI
stream
Stutter Fix
Terrain Textures Overhaul
Terrain Textures Overhaul - South
Textures
Ultra Realistic Live Leak Ragdolls
Uniform_Fix
VESTIGIA
VFX
W.E.R.O
WhyEm's Particles
Wickiup POI - Working Minimap
Wrong Angus Bull Fix